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NEWS
February 2025
The historic 1st annual conference of the Israeli Society for Chemical and Biological Sensing (ISBCS) took place at the Institute of Nanotechnology and Advanced Materials at Bar Ilan University on February 13th.
The scientific committee for the conference was composed of Prof. Amos Danielli, from the Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials at Bar Ilan University, Prof. Hadar Ben-Yoav, from Ben-Gurion University of the Negev, and Prof. Gili Bisker, from Tel Aviv University.
Generously sponsored by ILMAR and BioAnalytics Ltd, the conference brought together numerous biomedical researchers, as well as representatives from the Directorate of Defense Research and Development (DDR&D, MAFAT), the Israel Innovation Authority, and the Ministry of Innovation, Science, and Technology. The organizing committee expresses sincere gratitude to the distinguished speakers from prominent academic institutions across Israel: Prof. Ester Segal (Technion), Prof. Gil Shalev (Ben-Gurion University), Prof. Ariel Kushmaro (Ben-Gurion University), Dr. Zvi Yaari (Hebrew University), Prof. David Margulies (Weizmann Institute of Science), Prof. Rachela Popovtzer (Bar Ilan University), and Prof. Ramez Daniel (Technion).
The committee also extends its thanks to the 40 students who participated in the poster competition, showcasing their research contributions.
As part of the program, the attendees had the opportunity to learn about some of the ongoing research in our Optical Imaging and Biosensing laboratory, presented by our Biological Lab Manager, Dr. Linoy Golani-Zaidie, and our Ph.D. students, Shmuel Burg and Sophie Terenteva, who shared their latest research through three different posters.
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February 2025
On January 26th, our M.Sc. student, Sophie Terenteva—who is currently continuing her research in our lab as a Ph.D. student—presented her research work at the No
Abstract
Detecting low concentrations of biomarkers is essential in clinical laboratories. To improve analytical sensitivity, especially in identifying fluorescently labeled molecules, typical optical detection systems, consisting of a photodetector or camera, utilize time-resolved measurements. Taking a different approach, magnetic modulation biosensing (MMB) is a novel technology that combines fluorescently labeled probes and magnetic particles to create a sandwich assay with the target molecules. By concentrating the target molecules and then using time-resolved measurements, MMB provides the rapid and highly sensitive detection of various biomarkers. Here, we propose a novel signal-processing algorithm that enhances the detection and estimation of target molecules at low concentrations. By incorporating both temporally and spatially resolved measurements using human interleukin-8 as a target molecule, we show that the new algorithm provides a 2–4-fold improvement in the limit of detection and an ~25% gain in quantitative resolution.
Keywords: immunoassays, magnetic beads, image processing, signal processing, in vitro diagnostics
1. Introduction
Detecting target molecules, such as proteins, antibodies, or specific DNA sequences, within a population of molecules is critical in medical laboratory science. A typical molecule detection system consists of three elements: (a) a biological recognition component that captures the target molecule, (b) a reporting element, such as a fluorescent dye, quantum dots, or gold nanoparticles, that translates the biorecognition event into an analytically valuable signal, and (c) a detector that captures the physical signal [1]. Due to their high sensitivity [2,3,4] and multiplexing capabilities [5], optical sensing techniques [2,3,5,6] form the backbone of clinical diagnostic devices. In a typical fluorescence-based assay, the biological recognition element is immobilized onto a capture surface, such as a 96-well plate [7 Open access peer-reviewed chapter - ONLINE FIRST Written By Shmuel Burg, Michael Margulis and Amos Danielli Submitted: 29 October 2024Reviewed: 11 November 2024Published: 27 January 2025 DOI: 10.5772/intechopen.1008860 Current Developments in Biosensor Applications and Smart Strategi...Edited by Selcan Karakuş From the Edited Volume Associate Prof. Selcan Karakuş 4 Total Chapter Downloads on intechopen.com Rapid, sensitive, and high-throughput detection of biomarkers at low concentrations is crucial for early disease diagnosis. Many sensitive immunoassays use magnetic beads to capture fluorescently labeled targets, but quantifying these targets involves detecting the fluorescent signal from individual beads, which is time-consuming and requires a costly detection system. Additionally, there is often a trade-off between sensitivity, speed, throughput, and ease of use. A new technology, high-throughput optical modulation biosensing (OMB), enables reading a 96-well plate within 10 minutes. In OMB, a cylindrical permanent magnet immobilizes the magnetic beads at the illumination spot. Then, a laser beam is manipulated between the magnetic beads cluster and the background solution, effectively subtracting noise and reducing the need for washing and separation steps, which are usually incorporated in heterogeneous assays. This technology has evolved into a fully automated platform with high sensitivity and throughput, allowing much faster turnaround time and better sensitivity than the state-of-the-art methods, like enzyme-linked immunosorbent assay (ELISA) (for protein detection) and real-time PCR (for RNA/DNA detection). Here, we provide a comprehensive review of this technology, it From Concept to Commercialization: High-Throughput Optical Modulation Biosensing for Detecting Low Concentrations of Biomarkers
Current Developments in Biosensor Applications and Smart Strategies [Working Title]
Abstract
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